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YKJ-124

Chemical Structure : YKJ-124

CAS No.:

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YKJ-124 (YKJ124)

Catalog No.: PC-27981Not For Human Use, Lab Use Only.

YKJ-124 is a specific, nonsteroidal small molecule inhibitor of cholesterol transfer protein Aster-A without affecting other cholesterol transport pathways, attenuates the suppression of nuclear SREBP2 by cyclodextrin-cholesterol in CHO cells, increases plasma membrane accessible cholesterol and potentiates store-operated Ca2+ entry in Th17 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YKJ-124 is a specific, nonsteroidal small molecule inhibitor of cholesterol transfer protein Aster-A without affecting other cholesterol transport pathways, attenuates the suppression of nuclear SREBP2 by cyclodextrin-cholesterol in CHO cells, increases plasma membrane accessible cholesterol and potentiates store-operated Ca2+ entry in Th17 cells.

Physicochemical Properties

M.Wt 322.36
Formula C19H18N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(6-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)quinolin-2-yl)propan-2-ol

References

1. Hyunsoo Kim, et al. Proc Natl Acad Sci U S A. 2026 Sep 8;123(36):e2617638123.

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