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Chemical Structure : YLIU-5-162-1
Catalog No.: PC-20901Not For Human Use, Lab Use Only.
YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib.
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YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib.
YLIU-4-105-1 shows pure JAK2 selectivity, inhibits pSTAT1 (Y701) and in some cases pERK1/2 (T202/Y204) to varying extents, but does not inhibit pAKT (T308).
YLIU-4-105-1 is more potent against JAK2 V617F-dependent SET2 cells.
YLIU-4-105-1 (50 mg/kg or 75 mg/kg, IP daily) shows abdominal ascites, intraabdominal drug precipitate, and dilated loops of bowel on rhEPO-induced polycythemia mouse model.
| M.Wt | 605.67 | |
| Formula | C32H34F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew L Arwood, et al. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12.
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