Chemical Structure : YM-1
CAS No.: 409086-68-6
Catalog No.: PC-62198Not For Human Use, Lab Use Only.
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.
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YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.
YM-1 enhances client protein ubiquitination and polyQ AR degradation.
YM-1 alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA).
YM-1 also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.
M.Wt | 417.97 | |
Formula | C20H20ClN3OS2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride |
1. Wang AM, et al. Nat Chem Biol. 2013 Feb;9(2):112-8.
2. Morishima Y, et al. Biochemistry. 2011 Aug 23;50(33):7146-56.
3. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40.
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