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YM-344484

Chemical Structure : YM-344484

CAS No.: 671205-14-4

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YM-344484 (YM344484)

Catalog No.: PC-20732Not For Human Use, Lab Use Only.

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

    Physicochemical Properties

    M.Wt 487.58
    Formula C28H30FN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-2-(1-(6-methylpyridazine-3-carbonyl)piperidin-4-ylidene)acetamide

    References

    1. Suzuki K, et al. Eur J Pharmacol. 2007 Jun 1;563(1-3):224-32.

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