YM-344484 | Dual CCR3/H1 antagonist | Probechem Biochemicals

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Chemical Structure : YM-344484

YM-344484 (YM344484)

Catalog No.: PC-20732Not For Human Use, Lab Use Only.

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	487.58
Formula	C28H30FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NN=C(C)C=C5)=O)CC\4

References

1. Suzuki K, et al. Eur J Pharmacol. 2007 Jun 1;563(1-3):224-32.

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YM-344484 (YM344484)

Biological Activity

Physicochemical Properties

References

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