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YQ128

Chemical Structure : YQ128

CAS No.: 2454246-18-3

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YQ128 (YQ-128)

Catalog No.: PC-21694Not For Human Use, Lab Use Only.

YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
50 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.
YQ128 dose dependently suppresses the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with IC50 of 1.59 uM.
YQ-128 (10 mg/kg) inhibits LPS-induced IL-1β production in wild-type but not Nlrp3-/- mice.

Physicochemical Properties

M.Wt 545.11
Formula C27H29ClN2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-3-thiopheneacetamide

References

1. Yuqi Jiang, et al. J Med Chem. 2019 Nov 14;62(21):9718-9731.

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