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Chemical Structure : YTK-2205
Catalog No.: PC-49727Not For Human Use, Lab Use Only.
YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation.
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YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation.
YTK-2205 (20 mg/kg) exerts therapeutic efficacy in paracetamol-induced liver damage, YTK-2205 successfully induced in vivo p62 oligomerization in livers from paracetamol-treated mice.
YTK-2205 limits JNK phosphorylation without altering either NRF2 pathway or mitochondrial RIPK1 translocation during paracetamol-induced hepatotoxicity.
YTK-2205 efficiently reduces ubiquitinated proteins in vivo by promoting selective autophagy, selectively accelerated the autophagic removal of damaged parts of the mitochondrion and ER.
YTK-2205 promotes p62-mediated ER-phagy and mitophagy in paracetamol-loaded primary murine hepatocytes.
| M.Wt | 391.51 | |
| Formula | C25H29NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hee-Yeon Kim, et al. Br J Pharmacol. 2022 Dec 7. doi: 10.1111/bph.16004.
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