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Chemical Structure : YX-I-1
Catalog No.: PC-38109Not For Human Use, Lab Use Only.
YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.
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YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.
YX-I-1 inhibits the aggregation of wt hIAPP, extending the t50 from 15.1 ± 0.2 h to 23.4 ± 1.0 h at a 1:7 molar ratio of peptide:inhibitor.
YX-I-1 inhibits primary nucleation, secondary nucleation and elongation of wt hIAP.
YX-A-1 is a useful chemical tools to study hIAPP aggregation.
| M.Wt | 435.528 | |
| Formula | C24H29N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yong Xu, et al. Nat Commun. 2022 Feb 24;13(1):1040.
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