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YX-I-1

Chemical Structure : YX-I-1

CAS No.: 2125571-84-6

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YX-I-1

Catalog No.: PC-38109Not For Human Use, Lab Use Only.

YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YX-I-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically inhibits amyloid formation.
    YX-I-1 inhibits the aggregation of wt hIAPP, extending the t50 from 15.1 ± 0.2 h to 23.4 ± 1.0 h at a 1:7 molar ratio of peptide:inhibitor.
    YX-I-1 inhibits primary nucleation, secondary nucleation and elongation of wt hIAP.
    YX-A-1 is a useful chemical tools to study hIAPP aggregation.

    Physicochemical Properties

    M.Wt 435.528
    Formula C24H29N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((2S,4R,6R)-4-acetamido-6-isopropyltetrahydro-2H-pyran-2-yl)phenyl)-2-(1H-benzo[d][1,2,3]triazol-1-yl)acetamide

    References

    1. Yong Xu, et al. Nat Commun. 2022 Feb 24;13(1):1040.

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