Catalog No.: PC-35998Not For Human Use, Lab Use Only.
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.
YZ129 also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells.
YZ129 directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression.
YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro.
YZ129 suppresses the growth of GBM xenografts in vivo.
Physicochemical Properties
M.Wt
300.317
Formula
C19H12N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(isoquinolin-6-ylamino)naphthalene-1,2-dione
References
1. Liu Z, et al. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.
