You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-Z-590
Z-590

Chemical Structure : Z-590

CAS No.: 433954-52-0

Z-590 (Z590)

Catalog No.: PC-35242Not For Human Use, Lab Use Only.

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.
    Z-590 significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells.
    Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.

    Physicochemical Properties

    M.Wt 376.43
    Formula C21H16N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-[(biphenyl-4-ylcarbonyl)carbamothioyl]amino benzoic acid

    References

    1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157.

    2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: