Z-590 |CAS:433954-52-0 Probechem Biochemicals

Chemical Structure : Z-590

Z-590 (Z590)

Catalog No.: PC-35242Not For Human Use, Lab Use Only.

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.

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Biological Activity

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.
Z-590 significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells.
Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.

Physicochemical Properties

M.Wt	376.43
Formula	C21H16N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(biphenyl-4-ylcarbonyl)carbamothioyl]amino benzoic acid

References

1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157.

2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144.

Z-590 (Z590)

Biological Activity

Physicochemical Properties

References

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