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Z-Arg-Lys-AOMK

Chemical Structure : Z-Arg-Lys-AOMK

CAS No.: 2810056-57-4

Z-Arg-Lys-AOMK (Cathepsin B inhibitor)

Catalog No.: PC-38309Not For Human Use, Lab Use Only.

Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM).
Z-Arg-Lys-AOMK displayed high specificity for cathepsin B compared to other lysosomal cysteine cathepsins.
Z-Arg-Lys-AOMK selectively inhibits cathepsin B cleavage of peptides at neutral cytosolic pH compared to acidic lysosomal pH conditions.
Z-Arg-Lys-AOMK completely inhibited cathepsin B in human neuroblastoma cell lysates at 1 uM.
Z-Arg-Lys-AOMK is cell permeable and inhibits intracellular cathepsin B.

Physicochemical Properties

M.Wt 582.702
Formula C30H42N6O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-7-amino-3-((S)-2-(((benzyloxy)carbonyl)amino)-5-guanidinopentanamido)-2-oxoheptyl 2,6-dimethylbenzoate

References

1. Michael C Yoon, et al. ACS Chem Biol. 2021 Sep 17;16(9):1628-1643.

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