Z-DEVD-FMK | Caspase-3 inhibitor | Probechem Biochemicals

Chemical Structure : Z-DEVD-FMK

CAS No.: 210344-95-9

Z-DEVD-FMK (Apoptosis inhibitor)

Catalog No.: PC-43046Not For Human Use, Lab Use Only.

Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 uM, inhibits apoptosis.

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1 mg	$88	In stock
5 mg	$198	In stock
10 mg	$328	In stock
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Biological Activity

Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 uM, inhibits apoptosis.
Z-DEVD-FMK affects the survival and function of platelets in platelet concentrate during storage, blocks the geranylgeraniol-induced DNA fragmentation in human leukemia cells.
Z-DEVD-FMK abolishes the apoptosis, CPP32/Mch3alpha processing and the increase in CPP32-like protease activity induced by TGF-beta1 in rat hepatocytes.

Physicochemical Properties

M.Wt	668.6646
Formula	C30H41FN4O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33.33 mg/mL
Chemical Name/SMILES	L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester

References

1. Inayat-Hussain SH, et al. Hepatology. 1997 Jun;25(6):1516-26.

2. Lee YS, et al. Mol Cells. 1998 Jun 30;8(3):272-9.

3. Kanthasamy AG, et al. Free Radic Biol Med. 2006 Nov 15;41(10):1578-89.

4. Springer JE, et al. Nat Med. 1999 Aug;5(8):943-6.

Z-DEVD-FMK (Apoptosis inhibitor)

Biological Activity

Physicochemical Properties

References

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