Chemical Structure : Z1149421873
CAS No.:
2759347-27-6
Z1149421873
(Z11)
Catalog No.: PC-26503Not For Human Use, Lab Use Only.
Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs.
Z11 significantly suppressed TGF-β1-induced NAP1L1 protein levels in a dose-dependent manner in PMCFs.
Z11 attenuates TGF-β1-induced adult mice cardiac fibroblast activation and collagen production in vitro.
Z11 suppresses AKT/mTOR signaling pathway by modulating NAP1L1/YAP1 interaction in PMCFs.
Z11 regulates YAP1 ubiquitination to activate the AKT/mTOR signaling pathway.
Z11 attenuates post-MI-induced cardiac fibrosis progression in mice.
Physicochemical Properties
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M.Wt
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442.49
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Formula
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C26H23FN4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2-fluoro-4-methylphenyl)-N'-(2-(naphthalen-2-yl)acetyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbohydrazide
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References
1. Yu T, et al. Eur J Pharmacol. 2026 Jan 12;1011:178440.
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