Z583 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : Z583

Z583 (JAK3 inhibitor Z583, Z-583)

Catalog No.: PC-49274Not For Human Use, Lab Use Only.

Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes.

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Biological Activity

Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes.
Z583 completely inhibited the γc cytokine signaling and sufficiently blocked the development of inflammatory response in RA model, while sparing hematopoiesis.

Physicochemical Properties

M.Wt	418.461
Formula	C21H22N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6-((1-(2-methoxyethyl)-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)acrylamide

References

1. Chengjuan Chen, et al. Sci Adv. 2022 Aug 19;8(33):eabo4363.

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Z583 (JAK3 inhibitor Z583, Z-583)

Biological Activity

Physicochemical Properties

References

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