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Chemical Structure : Z583
Catalog No.: PC-49274Not For Human Use, Lab Use Only.
Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes.
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Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes.
Z583 completely inhibited the γc cytokine signaling and sufficiently blocked the development of inflammatory response in RA model, while sparing hematopoiesis.
| M.Wt | 418.461 | |
| Formula | C21H22N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chengjuan Chen, et al. Sci Adv. 2022 Aug 19;8(33):eabo4363.
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