ZAP-70 inhibitor 26

Chemical Structure : ZAP-70 inhibitor 26

Catalog No.: PC-21065Not For Human Use, Lab Use Only.

ZAP-70 inhibitor 26 is a potent, highly selective ZAP-70 kinase inhibitor with IC50 of 88 nM, shows high selectivity over structurally related Syk (IC50>10 uM).

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Biological Activity

ZAP-70 inhibitor 26 is a potent, highly selective ZAP-70 kinase inhibitor with IC50 of 88 nM, shows high selectivity over structurally related Syk (IC50>10 uM).
ZAP-70 inhibitor 26 also shows no activity against a panel of kinases, including Lck, PKCβ2, EGFR, Src, ERK-1, JNK 1, and p38α (IC50>10 uM).

Physicochemical Properties

M.Wt	516.56
Formula	C27H28N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OCC)/C=C/C1=CC=C(CNC2=NC(NC3=CC(OC)=CC(OC)=C3)=C(C(N)=O)C4=NC=CN24)C=C1

References

1. Akihito Hirabayashi, et al. Bioorg Med Chem. 2009 Jan 1;17(1):284-94.

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