Chemical Structure : ZDHHC2 inhibitor TTZ1
CAS No.:
103180-92-3
ZDHHC2 inhibitor TTZ1
(Tetrazole-1)
Catalog No.: PC-25634Not For Human Use, Lab Use Only.
zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) is a specific enzymatic inhibitor of palmitoyltransferase ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 4.7 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) is a specific enzymatic inhibitor of palmitoyltransferase ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 4.7 uM.
TTZ-1 inhibits zDHHC2-mediated SNAP25 S-acylation in cells with IC50 of 15 uM in HEK293T cells transfected with plasmids encoding GFP-tagged SNAP25b and HA-tagged zDHHC2.
TTZ-1 shows no effect on S-acylation of SNAP25 by zDHHC3 and zDHHC7.
TTZ-1 (25 uM) significantly inhibits PSD95-mCHERRY S-acylation by zDHHC2 and zDHHC15 in HEK293T cells.
TTZ-1 restores ACSL4 protein, reactivates ferroptosis, and reverses enzalutamide resistance in CRPC cell lines and patient-derived xenograft models.
Physicochemical Properties
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M.Wt
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436.52
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Formula
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C23H28N6O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(1H-tetrazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4-(heptyloxy)benzamide
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References
1. Salaun C, et al. J Biol Chem. 2022 Oct;298(10):102469.
2. Shao S, et al. Adv Sci (Weinh). 2025 Oct 23:e14077.
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