ZG-2492 | LDHA inhibitor | Probechem Biochemicals

Chemical Structure : ZG-2492

ZG-2492 (ZG2492)

Catalog No.: PC-24993Not For Human Use, Lab Use Only.

ZG-2492 is a potent, orally bioavailable inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 156 nM.

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Biological Activity

ZG-2492 is a potent, orally bioavailable inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 156 nM.
ZG-2492 exhibits cytotoxicity activity against pancreatic Mia PaCa-2 cells with IC50 of 2.4 uM, shows no toxicity to normal HUVEC cells (IC50>40 uM).
ZG-2492 inhibits lactate production in pancreatic Mia PaCa-2 cells with IC50 of 3.6 uM.
ZG-2492 binds LDHA with a dissociation constant (Kd) of 3.99 μM in SPR assays.
ZG-2492 (1-10 uM) induces apoptosis in Mia PaCa-2 cells.
ZG-2492 (100 mg/kg, oral) exhibited antitumor effects in Mia PaCa-2 xenograft nude mouse model.

Physicochemical Properties

M.Wt	448.92
Formula	C20H21ClN4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-(N-(2-Chloro-5-cyanophenyl)sulfamoyl)phenyl)piperazin-1-yl)propanoic Acid

References

1. Qijie Gong, et al. J Med Chem. 2025 Jul 11. doi: 10.1021/acs.jmedchem.5c00359.

ZG-2492 (ZG2492)

Biological Activity

Physicochemical Properties

References

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