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ZG111

Chemical Structure : ZG111

CAS No.: 2999671-63-3

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ZG111

Catalog No.: PC-23497Not For Human Use, Lab Use Only.

ZG111 is a potent ClpP agonist with EC50 of 1.19 uM, binds to ClpP and promotes the ClpP-mediated degradation of respiratory chain complexes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZG111 is a potent ClpP agonist with EC50 of 1.19 uM, binds to ClpP and promotes the ClpP-mediated degradation of respiratory chain complexes.
ZG111 exerts an antiproliferation effect on PDAC cells via aberrant ClpP activation in mitochondria.
ZG111 activates the JNK/c-Jun pathway and triggers an ER stress response in a ClpP-dependent manner.
ZG111 exerts antitumor effects in PDAC mice models with different KRAS genetic types.

Physicochemical Properties

M.Wt 577.52
Formula C30H33BrN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6S,9aS)-N-(4-bromobenzyl)-6-((S)-sec-butyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

References

1. Wang P, et al. Cell Chem Biol. 2022 Sep 15;29(9):1396-1408.e8.

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