ZHAWOC8655

Chemical Structure : ZHAWOC8655

CAS No.: 1257657-02-5

Catalog No.: PC-26791Not For Human Use, Lab Use Only.

ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$148	In stock
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Biological Activity

ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15.

Physicochemical Properties

M.Wt	356.43
Formula	C22H20N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(8-Methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5-phenyl-1H-pyrazol-3-yl)methanone

References

1. Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.

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ZHAWOC8655

Biological Activity

Physicochemical Properties

References

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