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ZIKV inhibitor K22

Chemical Structure : ZIKV inhibitor K22

CAS No.: 2141978-86-9

ZIKV inhibitor K22

Catalog No.: PC-35651Not For Human Use, Lab Use Only.

ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i).

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    Biological Activity

    ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i).
    ZIKV inhibitor K22 inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM.
    ZIKV inhibitor K22 acts on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.

    Physicochemical Properties

    M.Wt 505.412
    Formula C27H25BrN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide

    References

    1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18.

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