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ZINC13407541

Chemical Structure : ZINC13407541

CAS No.: 2310258-52-5

ZINC13407541 (ZINC 13407541)

Catalog No.: PC-72719Not For Human Use, Lab Use Only.

ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM.

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    Biological Activity

    ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM.
    ZINC13407541 binds to FGF-23 and disrupts its interaction with the FGFR1/α-KL complex, inhibits FGF-23 activation of the FGFR/a-KL receptor complex.
    ZINC13407541 caused significant -60 and 100% inhibition of FGF-23 stimulation of ERK reporter activity at 2.5 and 10 μM, respectively, in HEK293T cells, did not inhibit FGFR activation of these FGF ligands.
    ZINC13407541 significantly increased serum phosphate, PTH, and 1,25(OH)2D, decreased serum abundance of FGF-23 by about 35% in Dmp1-null mice.

    Physicochemical Properties

    M.Wt 213.28
    Formula C14H15NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-2-((E)-styryl)cyclopent-1-ene-1-carbaldehyde oxime

    References

    1. Xiao Z, et al. Sci Signal. 2016 Nov 22;9(455):ra113.

    2. Xiao Z, et al. Mol Pharmacol. 2022 Mar 26:MOLPHARM-AR-2021-000471.

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