ZINC621433144 | D4 agonist | Probechem Biochemicals

Chemical Structure : ZINC621433144

ZINC621433144 (ZINC 621433144)

Catalog No.: PC-20978Not For Human Use, Lab Use Only.

ZINC621433144 is a Gi-biased, high-affinity full agonist of dopamine D4 receptor with Ki of 4.3 nM and cAMP EC50 of 0.18 nM.

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Biological Activity

ZINC621433144 is a Gi-biased, high-affinity full agonist of dopamine D4 receptor with Ki of 4.3 nM and cAMP EC50 of 0.18 nM.
ZINC621433144 displays no affinity for D2 and D3 receptors.
ZINC621433144 shows EC50 of 0.56 and 2.3 nM in Gi BRET and Arrestin BRET assays, respectively.

Physicochemical Properties

M.Wt	301.43
Formula	C18H27N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1[C@@H](C)C2=C(C=CC=C2)C1)N[C@H]3CN(C(C)C)C[C@@H]3C

References

1. Jiankun Lyu, et al. Nature. 2019 Feb;566(7743):224-229.

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ZINC621433144 (ZINC 621433144)

Biological Activity

Physicochemical Properties

References

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