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ZIP14 inhibitor PPTD

Chemical Structure : ZIP14 inhibitor PPTD

CAS No.: 3060083-14-6

ZIP14 inhibitor PPTD

Catalog No.: PC-25881Not For Human Use, Lab Use Only.

ZIP14 inhibitor PPTD is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZIP14 inhibitor PPTD is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8.

Physicochemical Properties

M.Wt 371.91
Formula C21H26ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-oxo-8-phenethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-ium chloride

References

1. Takafumi Hara, et al. bioRxiv. [Preprint]. 2025 Oct 23:2025.10.23.682519.

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