Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ZL0420
CAS No.: 2229039-45-4
Catalog No.: PC-35096Not For Human Use, Lab Use Only.
ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
ZL0420 (ZL-0420) displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM).
ZL0420 (ZL-0420) disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM).
ZL0420 (ZL-0420) blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.
| M.Wt | 296.33 | |
| Formula | C16H16N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-6-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one |
|
1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151.
2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
