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Chemical Structure : ZL0580
CAS No.: 2377151-10-3
Catalog No.: PC-73041Not For Human Use, Lab Use Only.
ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation.
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $438 | In stock | |
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ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation.
ZL0580 induces epigenetic reprogramming of HIV LTR in J-Lat cells, suppresses HIV in in vitro HIV-infected human CD4+ T cells, did not significantly alter HIV DNA levels, but reduced HIV transcription in PBMCs.
ZL0580 suppresses HIV transcription ex vivo in PBMCs of viremic HIV-infected participants.
ZL0580 more selectively binds to the BRD4 BD1 domain (IC50=163 nM) instead of BD2 (IC50=1071 nM).
ZL0580 also displays approximately 6- to 11-fold selectivity for BRD4 over other BET proteins (IC50 ranged from approximately 0.9 to 1.9 μM) as well as over a non-BET BD protein, CBP (IC50 >10 uM).
ZL0580 inhibits Tat transactivation and key factors in HIV transcription elongation.
| M.Wt | 532.538 | |
| Formula | C25H23F3N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-phenyl-1-((4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)sulfonyl)pyrrolidine-2-carboxamide |
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1. Niu Q, et al. J Clin Invest. 2019 Jul 22;129(8):3361-3373.
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