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Chemical Structure : ZL0590
CAS No.: 2230496-99-6
Catalog No.: PC-21739Not For Human Use, Lab Use Only.
ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $558 | In stock | |
| 100 mg | Get quote |
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ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1.
ZL0590 inhibits Poly(I:C)-induced expression of inflammatory genes CIG5 and IL-6 in hSAECs with IC50 of 0.2 and 0.37 uM, respectively.
ZL0590 is 10-fold more selective over BRD4 BD2, BRD2 BD1, and BRD2 BD2, highly selective over other BET members (e.g., BRD3 and BRDT) and non-BET protein (e.g., CBP).
ZL0590 binds selectively to WT BRD4-BD1 but not WT BRD4-BD2 nor E151-mutated BRD4-BD1.
ZL0590 (10 mg/kg, po) blocked poly(I:C)-induced acute airway inflammation in mice.
| M.Wt | 512.55 | |
| Formula | C23H27F3N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]- |
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1. Liu Z, et al. J Med Chem. 2022 Feb 10;65(3):2388-2408.
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