ZLDI-8 (IAC-8) | ADAM17 inhibitor | Probechem Biochemicals

Chemical Structure : ZLDI-8

CAS No.: 667880-38-8

ZLDI-8 (ZLDI8, IAC-8)

Catalog No.: PC-35373Not For Human Use, Lab Use Only.

ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17 (TNFα-converting enzyme, or TACE), significantly decreases the level of NICD and accumulation of NICD in the nucleus.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$358	In stock
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Biological Activity

ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17 (TNFα-converting enzyme, or TACE), significantly decreases the level of NICD and accumulation of NICD in the nucleus.

ZLDI-8 (IAC-8) exhibits cytotoxic acitviity against MHCC97-H cells with IC50 of 5.32 uM, reduces the expression of pro-survival/anti-apoptosis regulators, Survivin and cIAP1/2, also increases the expression of epithelial marker E-Cadherin and reduces mesenchymal markers N-Cadherin and Vimentin in HCC cells.

ZLDI-8 (IAC-8) significantly disrupted the activity of Notch pathway in HCC cells and inhibits the epithelial-mesenchymal transition (EMT) process of HCC cells.

ZLDI-8 (IAC-8) treatment enhances the susceptibility of HCC cells to Sorafenib, Etoposide, and Paclitaxel both in vitro and in vivo.

Physicochemical Properties

M.Wt	433.526
Formula	C24H23N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1-(2-(2,4-dimethylphenoxy) ethyl) -2-methyl-1H-indol-3-yl) methylene) -2-thioxodihydropyrimidine-4,6 (1H,5H) -dione

References

1. Zhang Y, et al. Cell Death Dis. 2018 Jul 3;9(7):743.

ZLDI-8 (ZLDI8, IAC-8)

Biological Activity

Physicochemical Properties

References

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