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Chemical Structure : ZLDI-8
CAS No.: 667880-38-8
Catalog No.: PC-35373Not For Human Use, Lab Use Only.
ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $138 | In stock | |
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote |
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ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus.
ZLDI-8 (IAC-8) exhibits cytotoxic acitviity against MHCC97-H cells with IC50 of 5.32 uM, reduces the expression of pro-survival/anti-apoptosis regulators, Survivin and cIAP1/2, also increases the expression of epithelial marker E-Cadherin and reduces mesenchymal markers N-Cadherin and Vimentin in HCC cells.
ZLDI-8 (IAC-8) significantly disrupted the activity of Notch pathway in HCC cells and inhibits the epithelial-mesenchymal transition (EMT) process of HCC cells.
ZLDI-8 (IAC-8) treatment enhances the susceptibility of HCC cells to Sorafenib, Etoposide, and Paclitaxel both in vitro and in vivo.
| M.Wt | 433.526 | |
| Formula | C24H23N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((1-(2-(2,4-dimethylphenoxy) ethyl) -2-methyl-1H-indol-3-yl) methylene) -2-thioxodihydropyrimidine-4,6 (1H,5H) -dione |
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1. Zhang Y, et al. Cell Death Dis. 2018 Jul 3;9(7):743.
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