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Chemical Structure : ZM-447439
CAS No.: 331771-20-1
Catalog No.: PC-42348Not For Human Use, Lab Use Only.
ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively.
ZM-447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity, inhibits the growth and tumorigenicity of a panel of ATC derived cell lines (CAL-62, 8305C, 8505C and BHT-101) with IC50 of 0.5-5 uM.
ZM447439-treated cells exit mitosis with normal kinetics, accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint.
| M.Wt | 513.5875 | |
| Formula | C29H31N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]- |
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1. Baldini E, et al. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15.
2. Gadea BB, et al. Mol Biol Cell. 2005 Mar;16(3):1305-18.
3. Ditchfield C, et al. J Cell Biol. 2003 Apr 28;161(2):267-80.
4. Lane SI, et al. Reproduction. 2010 Oct;140(4):521-30.
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