ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor (A2AR) antagonist with rat PC12 binding pIC50 of 9.52.
ZM241385 shows low affinity for A3 receptors (pIC50=3.82).
ZM241385 antagonizes vasodilatation of the coronary bed produced by 2-CADO and CGS21680 with pA2 of 8.57 and 9.02, respectively, in guinea-pig isolated Langendorff hearts.
ZM241385 selectively attenuates the mean arterial blood pressure response produced by exogenous adenosine in conscious spontaneously hypertensive rats (3-10 mg/kg, p.o.).
