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Chemical Structure : ZM241385
CAS No.: 139180-30-6
Catalog No.: PC-45641Not For Human Use, Lab Use Only.
ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor (A2AR) antagonist with rat PC12 binding pIC50 of 9.52.
ZM241385 shows low affinity for A3 receptors (pIC50=3.82).
ZM241385 antagonizes vasodilatation of the coronary bed produced by 2-CADO and CGS21680 with pA2 of 8.57 and 9.02, respectively, in guinea-pig isolated Langendorff hearts.
ZM241385 selectively attenuates the mean arterial blood pressure response produced by exogenous adenosine in conscious spontaneously hypertensive rats (3-10 mg/kg, p.o.).
| M.Wt | 337.336 | |
| Formula | C16H15N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]- |
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1. Poucher SM, et al. Br J Pharmacol. 1995 Jul;115(6):1096-102.
2. Guo D, et al. ChemMedChem. 2014 Apr;9(4):752-61.
3. Poucher SM, et al. J Pharm Pharmacol. 1996 Jun;48(6):601-6.
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