You are here:Home-Chemical Inhibitors & Agonists-GPCR-Adenosine Receptor-ZM241385
ZM241385

Chemical Structure : ZM241385

CAS No.: 139180-30-6

ZM241385 (ZM-241385;ZM 241385)

Catalog No.: PC-45641Not For Human Use, Lab Use Only.

ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $148 In stock
50 mg $238 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor (A2AR) antagonist with rat PC12 binding pIC50 of 9.52.
ZM241385 shows low affinity for A3 receptors (pIC50=3.82).
ZM241385 antagonizes vasodilatation of the coronary bed produced by 2-CADO and CGS21680 with pA2 of 8.57 and 9.02, respectively, in guinea-pig isolated Langendorff hearts.
ZM241385 selectively attenuates the mean arterial blood pressure response produced by exogenous adenosine in conscious spontaneously hypertensive rats (3-10 mg/kg, p.o.).

Physicochemical Properties

M.Wt 337.336
Formula C16H15N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-

References

1. Poucher SM, et al. Br J Pharmacol. 1995 Jul;115(6):1096-102.

2. Guo D, et al. ChemMedChem. 2014 Apr;9(4):752-61.

3. Poucher SM, et al. J Pharm Pharmacol. 1996 Jun;48(6):601-6.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: