ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM.
ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2.
ZM39923 alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival.
ZM39923 significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.
