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Chemical Structure : ZM39923 hydrochloride
CAS No.: 1021868-92-7
Catalog No.: PC-43112Not For Human Use, Lab Use Only.
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $468 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM; ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2; alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival; significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.
| M.Wt | 367.9117 | |
| Formula | C23H26ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-, hydrochloride (1:1) |
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1. Lai TS, et al. Chem Biol. 2008 Sep 22;15(9):969-78.
2. Zhang Z, et al. Oncol Lett. 2017 May;13(5):3191-3197.
3. Luo C, et al. Drug Discov Today. 2004 Mar 15;9(6):268-75.
4. Brown GR, et al. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9.
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