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Chemical Structure : ZNL-05-044
CAS No.: 3034411-38-3
Catalog No.: PC-38750Not For Human Use, Lab Use Only.
ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity.
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
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ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity.
ZNL-05-044 treatment leads to G2/M cell cycle arrest, impacts CDK11-dependent mRNA splicing in cells.
| M.Wt | 477.408 | |
| Formula | C21H22Cl2N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-amino-2-((2-methyl-6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)thiazol-5-yl)(2,6-dichlorophenyl)methanone |
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1. Li Z, et al. Eur J Med Chem. 2022 May 8;238:114433.
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