Catalog No.: PC-49260Not For Human Use, Lab Use Only.
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12.
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12.
ZSQ836 shows weak affinity (CDK9, GSK3A, and GSK3B) against a panel of 373 other kinases, exhibits comparable selectivity of organoarsenic CDK12/CDK13 covalent inhibitors to THZ531.
ZSQ836 is a potent antagonist against ovarian cancer, provokes DNA damage in ovarian cancer.
ZSQ836 is orally bioavailable and impairs tumor growth in vivo, and is efficacious in a murine ovarian tumor model.
ZSQ836 suppresses T cell proliferation and activation.
