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Chemical Structure : ZSQ836
Catalog No.: PC-49260Not For Human Use, Lab Use Only.
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12.
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ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12.
ZSQ836 shows weak affinity (CDK9, GSK3A, and GSK3B) against a panel of 373 other kinases, exhibits comparable selectivity of organoarsenic CDK12/CDK13 covalent inhibitors to THZ531.
ZSQ836 is a potent antagonist against ovarian cancer, provokes DNA damage in ovarian cancer.
ZSQ836 is orally bioavailable and impairs tumor growth in vivo, and is efficacious in a murine ovarian tumor model.
ZSQ836 suppresses T cell proliferation and activation.
| M.Wt | 627.054 | |
| Formula | C27H28AsClN6OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lin Cheng, et al. Cancer Res. 2022 Jul 20;CAN-22-0222.
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