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ZTM000990

Chemical Structure : ZTM000990

CAS No.: 115834-23-6

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ZTM000990 (SF 2446A1)

Catalog No.: PC-61810Not For Human Use, Lab Use Only.

ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
    ZTM000990 reduces levels of either c-Myc or cyclin D1 in HCT116 cells without effect on cyclin E level.
    ZTM000990 shows effects on growth of colon and prostate cancer cell lines (IC50=0.15-0.3 uM).

    Physicochemical Properties

    M.Wt 697.646
    Formula C34H35NO15
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Benzo[a]naphthacene-2-carboxylic acid, 11-[(6-deoxy-2,4-di-O-methyl-b-L-mannopyranosyl)amino]-5,6,6a,7,9,12,14,14a-octahydro-1,6,8,14a-tetrahydroxy-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-, methyl ester, (6R,6aS,14aR)-

    References

    1. Lepourcelet M, et al. Cancer Cell. 2004 Jan;5(1):91-102.

    2. Katoh M, et al. Clin Cancer Res. 2007 Jul 15;13(14):4042-5.

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