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Chemical Structure : ZTM000990
Catalog No.: PC-61810Not For Human Use, Lab Use Only.
ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
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ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
ZTM000990 reduces levels of either c-Myc or cyclin D1 in HCT116 cells without effect on cyclin E level.
ZTM000990 shows effects on growth of colon and prostate cancer cell lines (IC50=0.15-0.3 uM).
| M.Wt | 697.646 | |
| Formula | C34H35NO15 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lepourcelet M, et al. Cancer Cell. 2004 Jan;5(1):91-102.
2. Katoh M, et al. Clin Cancer Res. 2007 Jul 15;13(14):4042-5.
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