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Chemical Structure : ZW4864
CAS No.: 2632259-92-6
Catalog No.: PC-72708Not For Human Use, Lab Use Only.
ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.
ZW4864 dose-dependently suppresses β-catenin signaling activation, downregulates oncogenic β-catenin target genes, and abrogates invasiveness of β-catenin-dependent cancer cells.
ZW4864 effectively suppresses β-catenin target gene expression in the patient-derived xenograft mouse model.
ZW4864 is a selective chemical probe to explore β-catenin-related biology and a drug-like small-molecule β-catenin/BCL9 disruptor.
| M.Wt | 570.738 | |
| Formula | C33H42N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-(4-(1H-pyrazol-4-yl)benzyl)-N-cyclopropyl-1-(3-((2-methyl-1-oxo-1-(piperazin-1-yl)propan-2-yl)oxy)phenyl)piperidine-3-carboxamide |
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1. Zhen Wang, et al. J Med Chem. 2021 Aug 26;64(16):12109-12131.
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