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ZZW-115 hydrochloride

Chemical Structure : ZZW-115 hydrochloride

CAS No.: 10122-45-9

ZZW-115 hydrochloride (ZZW115)

Catalog No.: PC-22011Not For Human Use, Lab Use Only.

ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation.

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Biological Activity

ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation.
ZZW-115 demonstrates antitumor activity on a panel of 11 primary PDAC-derived cells and it was found to be efficient to kill the cancer cells with IC50 in the range from 0.84 μM (ANOR) to 4.93 μM (HN14).
ZZW-115 also inhibits the growth of other tumors-derived cells (IC50=0.42 μM (Hep2G cells) to 7.75 μM (SaO-2 cells)).
ZZW-115 induces pancreatic cell death by necrosis and apoptosis and inhibits the growth pancreatic xenografted tumors in vivo.

Physicochemical Properties

M.Wt 501.05
Formula C24H32ClF3N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine hydrochloride

References

1. Santofimia-Castaño P, et al. J Clin Invest. 2019 Mar 28;130. pii: 127223.

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