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Chemical Structure : Zevaquenabant
Catalog No.: PC-73457Not For Human Use, Lab Use Only.
Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual CB1 receptor/iNOS inhibitor.
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Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual CB1 receptor/iNOS inhibitor.
Zevaquenabant ((S)-MRI-1867) (3 mg/kg, p.o.) ameliorated obesity-induced kidney morphological and functional changes via decreasing kidney inflammation, fibrosis, oxidative stress, and renal injury.
The hybrid CB1R/iNOS inhibitor Zevaquenabant ((S)-MRI-1867) has greater antifibrotic efficacy than inhibition of CB1R alone.
(S)-MRI-1867 reduced hepatic steatosis and the rate of hepatic VLDL secretion, upregulated hepatic LDLR expression, and reduced the circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diet-induced obesity (DIO mice).
| M.Wt | 547.981 | |
| Formula | C25H21ClF3N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cinar R, et al. JCI Insight. 2017 Apr 20;2(8):e92281.
2. Udi S, et al. Br J Pharmacol. 2020 Jan;177(1):110-127.
3. Roger C, et al. Diabetes. 2020 Oct;69(10):2120-2132.
4. Cinar R, et al. Clin Transl Med. 2021 Jul;11(7):e471.
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