Catalog No.: PC-35604Not For Human Use, Lab Use Only.
Zifaxaban is a novel, potent, selective, direct and oral factor Xa (FXa) inhibitor with IC50 of 11.1 nM (human FXa), displays >10,000-fold selectivity than other serine proteases.
Zifaxaban is a novel, potent, selective, direct and oral factor Xa (FXa) inhibitor with IC50 of 11.1 nM (human FXa), displays >10,000-fold selectivity than other serine proteases.
Zifaxaban also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid.
Zifaxaban significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time.
Zifaxaban strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats.
