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Ziftomenib

Chemical Structure : Ziftomenib

CAS No.: 2134675-36-6

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Ziftomenib (KO-539, KO 539)

Catalog No.: PC-72438Not For Human Use, Lab Use Only.

Ziftomenib (KO-539) is a potent, highly selective, oral menin inhibitor, demonstrates encouraging clinical activity as monotherapy for relapsed/refractory NPM1-mutated (NPM1-m) and KMT2A-rearranged AML.

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5 mg $188 In stock
10 mg $298 In stock
25 mg $458 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ziftomenib (KO-539) is a potent, highly selective, oral menin inhibitor, demonstrates encouraging clinical activity as monotherapy for relapsed/refractory NPM1-mutated (NPM1-m) and KMT2A-rearranged AML.

Physicochemical Properties

M.Wt 717.875
Formula C33H42F3N9O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-

References

1. Cancer Discov. 2021 Feb;11(2):216-217.

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