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Chemical Structure : Zoligratinib
CAS No.: 1265229-25-1
Catalog No.: PC-45761Not For Human Use, Lab Use Only.
CH-5183284 (Debio-1347, Debio1347) is a potent, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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CH5183284 (Zoligratinib, Debio1347) is a potent, selective and orally available FGFR1/2/3 inhibitor with enzyme IC50 of 9.3/7.6/22 nM, respectively.
CH-5183284 displays >10-fold selectivity over FGFR4, and >100-fold over KDR, Src, and other kinases.
CH-5183284 displays preferential antitumor activity against cancer cells with various FGFR genetic alterations in a panel of 327 cancer cell lines and in xenograft models.
CH-5183284 can inhibit FGFR2 harboring one type of the gatekeeper mutation and blocks FGFR2 V564F-driven tumor growth.
| M.Wt | 356.3806 | |
| Formula | C20H16N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31mg/mL |
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| Chemical Name/SMILES |
Methanone, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl- |
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1. Ebiike H, et al. J Med Chem. 2016 Dec 8;59(23):10586-10600.
2. Nakanishi Y, et al. Mol Cancer Ther. 2014 Nov;13(11):2547-58.
3. Nakanishi Y, et al. Mol Cancer Ther. 2015 Dec;14(12):2831-9.
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