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anle145c

Chemical Structure : anle145c

CAS No.: 1204292-19-2

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anle145c

Catalog No.: PC-73121Not For Human Use, Lab Use Only.

anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.
    anle145c has a special mode of action in which anle145c-stabilized oligomers act as a thermodynamic sink for the preferred aggregation state of hIAPP and anle145c.
    anle145c prevents hIAPP fibril formation in solution, and converts preformed hIAPP fibrils into non-toxic oligomers.
    anle145c is a promising candidate to inhibit protein aggregation in case of T2DM.

    Physicochemical Properties

    M.Wt 426.064
    Formula C15H10Br2N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(5-(3,5-dibromophenyl)-1H-pyrazol-3-yl)benzene-1,2,3-triol

    References

    1. Saravanan MS, et al. Sci Rep. 2019 Dec 13;9(1):19023.

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