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Chemical Structure : anle145c
Catalog No.: PC-73121Not For Human Use, Lab Use Only.
anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.
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anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.
anle145c has a special mode of action in which anle145c-stabilized oligomers act as a thermodynamic sink for the preferred aggregation state of hIAPP and anle145c.
anle145c prevents hIAPP fibril formation in solution, and converts preformed hIAPP fibrils into non-toxic oligomers.
anle145c is a promising candidate to inhibit protein aggregation in case of T2DM.
| M.Wt | 426.064 | |
| Formula | C15H10Br2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Saravanan MS, et al. Sci Rep. 2019 Dec 13;9(1):19023.
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