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Chemical Structure : c-Myc inhibitor DJ34
Catalog No.: PC-49522Not For Human Use, Lab Use Only.
DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
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DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
DJ34 selectively kills BCR–Abl-positive leukemia cells, inhibits the c-Myc transcriptional program and activates the p53 program.
DJ34 induces depletion of c-Myc in a wide variety of tumor types, induces depletion of c-MYC mRNA.
DJ34 intercalates DNA and inhibits topoisomerase II but not topoisomerase I.
DJ34 induces cell cycle arrest, apoptosis, and differentiation.
DJ34 also shows anti- leukemic stem cells (LSCs) acitvities.
| M.Wt | 288.35 | |
| Formula | C18H16N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tadele DS, et al. J Biol Chem. 2021 Jan-Jun;296:100179.
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