Catalog No.: PC-49522Not For Human Use, Lab Use Only.
DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
DJ34 selectively kills BCR–Abl-positive leukemia cells, inhibits the c-Myc transcriptional program and activates the p53 program.
DJ34 induces depletion of c-Myc in a wide variety of tumor types, induces depletion of c-MYC mRNA.
DJ34 intercalates DNA and inhibits topoisomerase II but not topoisomerase I.
DJ34 induces cell cycle arrest, apoptosis, and differentiation.
DJ34 also shows anti- leukemic stem cells (LSCs) acitvities.
Physicochemical Properties
M.Wt
288.35
Formula
C18H16N4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(2-(1H-imidazol-4-yl)ethyl)acridin-9-amine
References
1. Tadele DS, et al. J Biol Chem. 2021 Jan-Jun;296:100179.
