Chemical Structure : cFLIP inhibitor OH14
CAS No.:
1018153-87-1
cFLIP inhibitor OH14
Catalog No.: PC-25677Not For Human Use, Lab Use Only.
cFLIP inhibitor OH14 is a small-molecule cFLIP-DED1 inhibitor, promotes TRAIL sensitivity via cFLIP, selectively inhibits cFLIP binding to the DISC and promotes TRAIL-mediated apoptosis in breast cancer cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
cFLIP inhibitor OH14 is a small-molecule cFLIP-DED1 inhibitor, promotes TRAIL sensitivity via cFLIP, selectively inhibits cFLIP binding to the DISC and promotes TRAIL-mediated apoptosis in breast cancer cell lines.
OH14 significantly sensitizes MCF-7 (ER+ve), BT474 (HER2+ve) and MDA-MB-231 (triple-negative) cell lines to TRAIL.
OH14 inhibits binding of cFLIP to the DISC components, impairs cFLIP recruitment to FADD complex and promotes cFLIP and caspase 8 cleavage.
OH14 significantly impairs breast cancer cell viability in primary derived and established cell culture.
Cellular FLICE-Like Inhibitory Protein (cFLIP) is an endogenous death-receptor associated protein
Physicochemical Properties
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M.Wt
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360.21
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Formula
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C14H11Cl2NO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2,4-dichloro-5-methylphenyl)sulfonamido)benzoic acid
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References
1. Gilda Giancotti, et al. The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL. bioRxiv. April 26, 2024.
2. Rhiannon French, et al. J Cancer Treatment Diagn. 2025 Aug 8;8(2):1-7.
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