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cGAS inhibitor XQ2B

Chemical Structure : cGAS inhibitor XQ2B

CAS No.: 2104728-28-9

cGAS inhibitor XQ2B (Cyclo(DPhe-ATRL-Dphe-PVRL))

Catalog No.: PC-26963Not For Human Use, Lab Use Only.

cGAS inhibitor XQ2B is potent, selective cyclopeptide inhibitor of Cyclic GMP-AMP synthase (cGAS), specifically binds to the DNA binding site of cGAS and blocks the binding of dsDNA with cGAS, subsequently inhibits dsDNA-induced liquid phase condensation and activation of cGAS, inhibits HSV-1-induced antiviral immune responses and enhances HSV-1 infection in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

cGAS inhibitor XQ2B is potent, selective cyclopeptide inhibitor of Cyclic GMP-AMP synthase (cGAS), specifically binds to the DNA binding site of cGAS and blocks the binding of dsDNA with cGAS, subsequently inhibits dsDNA-induced liquid phase condensation and activation of cGAS, inhibits HSV-1-induced antiviral immune responses and enhances HSV-1 infection in vitro and in vivo.

Physicochemical Properties

M.Wt 1201.46
Formula C59H92N16O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclo (D-Phe-Ala-Thr-Arg-Leu-D-Phe-Pro-Val-Arg-Leu)

References

1. Wang X, et al. Nat Commun. 2023 Oct 2;14(1):6132.

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