cGAS inhibitor cpd6

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Chemical Structure : cGAS inhibitor cpd6

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Catalog No.: PC-25369Not For Human Use, Lab Use Only.

cGAS inhibitor cpd6 is a potent, small moecule inhibitor of human cyclic GMP-AMP synthase (cGAS) with IC50 of 0.66 µM, modestly inhibits cGAMP levels by 29% at 30 µM in THP1 cells without detectable toxicity, and by 76% at 100 µM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	524.17
Formula	C16H15BrINO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3-bromo-4-ethoxyphenyl)sulfonyl)-2-(4-iodophenyl)acetamide

References

1. Alarcón-Espósito J, et al. bioRxiv [Preprint]. 2025 Aug 22:2025.08.18.670979.

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