cTYK2i Compound-A

Chemical Structure : cTYK2i Compound-A

Catalog No.: PC-24348Not For Human Use, Lab Use Only.

cTYK2i Compound-A (Cmpd-A) is a potent, specific and brain-penetrant TYK2 inhibitor (cTYK2i) with IC50 of 6.4 nM.

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Biological Activity

cTYK2i Compound-A (Cmpd-A) is a potent, specific and brain-penetrant TYK2 inhibitor (cTYK2i) with IC50 of 6.4 nM.
Cmpd-A is selective for the TYK2 JH2 domain versus all other tested JAK domains
Cmpd-A inhibits IL-6-induced pSTAT3 and GM-CSF-induced pSTAT5 with IC50 of 6.4 nM and 8.0 nM respectively.
Cmpd-A reduced type I IFN pathway activity in the brain.
Cmpd-A is protective by semitherapeutic delivery in the MOG35-55 EAE mouse model, reduces demyelination and gliosis.
Cmpd-A attenuates transcriptional inflammatory program and biomarker expression in EAE mouse models.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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