dCK1α-2

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Chemical Structure : dCK1α-2

Catalog No.: PC-23543Not For Human Use, Lab Use Only.

dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells.
dCK1α-2 is capable of inducing ternary complex formation between CRBN and CK1α in HEK293T cells.
dCK1α-2 degraded CK1α in vitro and demonstrated significant selectivity in TMT proteomic studies in MOLM13 AML cells.
dCK1α-2 (5-20 mg/kg) effectively inhibits MOLM13 xenograft tumor growth on MOLM13 growth in mouse xenograft models.

Physicochemical Properties

M.Wt	494.94
Formula	C24H23ClN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(5-(3-chloro-2-(morpholinomethyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Lu Huang, et al. JACS Au. 2024 Nov 8;4(11):4423-4434.

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dCK1α-2

Biological Activity

Physicochemical Properties

References

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