Catalog No.: PC-72071Not For Human Use, Lab Use Only.
hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.
hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.
hNPR1 inhibitor JS-11 inhibits hNPR1 receptor activity through a non-competitive mechanism.
hNPR1 inhibitor JS-11 reduced scratching responses to histamine-challenged mice and attenuated CYM5442-induced scratching in vivo, reduced the number of c-FOS-positive neurons to intradermal histamine challenge.
hNPR1 inhibitor JS-11 inhibited itching in a mouse model of contact dermatitis
