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Chemical Structure : hNPR1 inhibitor JS-11
CAS No.: 1394592-04-1
Catalog No.: PC-72071Not For Human Use, Lab Use Only.
hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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hNPR1 inhibitor JS-11 is a selective small-molecule inhibitor of NPPB receptor NPR1 (natriuretic peptide receptor 1), does not inhibit adenylate cyclases (ACs) family of enzymes.
hNPR1 inhibitor JS-11 inhibits hNPR1 receptor activity through a non-competitive mechanism.
hNPR1 inhibitor JS-11 reduced scratching responses to histamine-challenged mice and attenuated CYM5442-induced scratching in vivo, reduced the number of c-FOS-positive neurons to intradermal histamine challenge.
hNPR1 inhibitor JS-11 inhibited itching in a mouse model of contact dermatitis
| M.Wt | 408.502 | |
| Formula | C23H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide |
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1. Hans Jürgen Solinski, et al. Sci Transl Med. 2019 Jul 10;11(500):eaav5464.
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