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hPIF1 inhibitor 6

Chemical Structure : hPIF1 inhibitor 6

CAS No.: 1198088-48-0

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hPIF1 inhibitor 6

Catalog No.: PC-23216Not For Human Use, Lab Use Only.

hPIF1 inhibitor 6 is a specific small molecule inhibitor targeting the helicase activity of human PIF1 with IC50 of 36 uM for inhibition of FLhPIF1 helicase activity, 22-fold selective over hUPF1, inhibits hPIF1 DNA-binding and helicase activity in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

hPIF1 inhibitor 6 is a specific small molecule inhibitor targeting the helicase activity of human PIF1 with IC50 of 36 uM for inhibition of FLhPIF1 helicase activity, 22-fold selective over hUPF1, inhibits hPIF1 DNA-binding and helicase activity in vitro.
PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability.

Physicochemical Properties

M.Wt 280.35
Formula C16H12N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(2-aminothiazol-4-yl)phenyl)(phenyl)methanone

References

1. Wever MJA, et al. Nucleic Acids Res. 2024 Oct 17:gkae897.

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