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Chemical Structure : hTG2 inhibitor VA4
Catalog No.: PC-61052Not For Human Use, Lab Use Only.
hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency.
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hTG2 inhibitor VA4 (VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency.
hTG2 inhibitor VA4 inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context.
hTG2 inhibitor VA4 inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.
| M.Wt | 635.78 | |
| Formula | C33H41N5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927.
2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11.
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