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Chemical Structure : iCRT5
CAS No.: 18623-44-4
Catalog No.: PC-62165Not For Human Use, Lab Use Only.
iCRT5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $578 | In stock | |
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| 50 mg | Get quote | ||
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iCRT5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
iCRT5 specifically modulates the nuclear transcriptional activity of β-catenin while not affecting its cytoskeletal function in stabilizing adherens junctions at the cell membrane.
iCRT5 blocks Wnt/β-catenin-induced target genes and phenotypes in various mammalian and cancer cell lines.
| M.Wt | 367.44 | |
| Formula | C16H17NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid |
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1. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63.
2. Anastas JN, et al. Nat Rev Cancer. 2013 Jan;13(1):11-26.
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