iCRT5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
iCRT5 specifically modulates the nuclear transcriptional activity of β-catenin while not affecting its cytoskeletal function in stabilizing adherens junctions at the cell membrane.
iCRT5 blocks Wnt/β-catenin-induced target genes and phenotypes in various mammalian and cancer cell lines.
